Waltham – Mrs. Helen F. (Oates) Manning, of Waltham, died Tuesday, December 2, 2008 at Newton-Wellesley Hospital. She was 78. Born in Cambridge, a daughter of the late William F. and Helen F. (Ryan) Oates, she was raised in Watertown where she attended local schools. Helen moved from West Newton to Waltham in 1978. Until her retirement, Helen worked as a staff assistant at Brandeis University in Waltham. She leaves her children, William M. Manning and his wife, Jennifer, of Wilmington, Linda A. Imhof and her husband, Joe, of Nashua, New Hampshire, Donna M. Vallerand and her husband, Gary, of Waltham and Marsha F. Smith and her husband, Keith, of Burlington; her grandchildren, Jennifer, Andrea and Amy Vallerand, Laura and John Plaisted, Alex Imhof, Isabel Manning and Kristina, Rachel and Caitlyn Smith and many nieces and nephews. Helen was also a sister of the late William and Robert Oates, Barbara Morin and Mary McCarthy. Relatives and friends are invited to attend the Funeral at 10 a.m. Friday from The Joyce Funeral Home, 245 Main Street (Rte. 20), Waltham followed by a Funeral Mass in Saint Jude Church, 147 Main Street, Waltham at 11 a.m. Burial will be in Saint Patrick's Cemetery, Watertown. Visiting hours are Thursday from 4 to 8 p.m. Memorial donations may be made to Saint Jude Church, 147 Main Street, Waltham, MA 02453.